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DocHolliday
I'm having this queasy feeling in my gut about this corporate rush for a vaccine - especially by fledgling companies like Moderna who's been called out for possible stock manipulation.  I still believe a number of vaccines will be found, I just hope the human cost doesn't come with it.

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FILE - Small bottles labeled with a "Vaccine COVID-19" sticker and a medical syringe are seen in this illustration taken taken April 10, 2020.
FILE - Small bottles labeled with a "Vaccine COVID-19" sticker and a medical syringe are seen in this illustration taken taken April 10, 2020.

CHICAGO - A series of studies in mice of Moderna's COVID-19 vaccine lent some assurance that it may not increase the risk of more severe disease, and that one dose may provide protection against the novel coronavirus, according to preliminary data released Friday. 

Prior studies on a vaccine for SARS — a close cousin to the new virus that causes COVID-19 — suggests vaccines against this type of virus might have the unintended effect of causing more severe disease when the vaccinated person is later exposed to the pathogen, especially in individuals who do not produce an adequately strong immune response. 

Scientists have seen this risk as a hurdle to clear before vaccines can be safely tested in thousands of healthy people. 

While the data released by the U.S. National Institutes of Allergy and Infectious Disease (NIAID) and Moderna offered some assurance, the studies do not fully answer the question. 

"This is the barest beginning of preliminary information," said Dr. Gregory Poland, an immunologist and vaccine researcher at the Mayo Clinic who has seen the paper, which has yet to undergo peer review. 

Poland said the paper was incomplete and disorganized and that the numbers of animals tested were small. 

A man stands outside an entrance to a Moderna, Inc., building, Monday, May 18, 2020, in Cambridge, Mass. Moderna announced…
FILE - A man stands outside an entrance to a Moderna building in Cambridge, Massachusetts, May 18, 2020.

The authors said they have submitted the work to a top-tier journal. Moderna's vaccine is in midstage testing in healthy volunteers. Moderna said Thursday that it plans to begin final-stage trials enrolling 30,000 people in July. 

In the animal studies, mice received one or two shots of a variety of doses of Moderna's vaccine, including doses considered not strong enough to elicit a protective immune response. Researchers then exposed the mice to the virus. 

Subsequent analyses suggest "sub-protective" immune responses do not cause what is known as vaccine-associated enhanced respiratory disease, a susceptibility to more severe disease in the lungs. 

"Subprotective doses did not prime mice for enhanced immunopathology following [exposure]," Dr. Barney Graham of the Vaccine Research Center at NIAID and colleagues wrote in the manuscript, posted on the bioRxiv website. 

Further testing suggested the vaccine induces antibody responses to block the virus from infecting cells. 

The vaccine also appeared to protect against infection by the coronavirus in the lungs and noses without evidence of toxic effects, the team wrote. 

They noted the mice that received just one dose before exposure to the virus seven weeks later were "completely protected against lung viral replication," suggesting a single vaccination prevented the virus from replicating in the lungs. 

"At first glance, it looks promising in inducing neutralizing antibody protection in mice," Dr. Peter Hotez, a researcher at Baylor College of Medicine, said in an email. He had not reviewed the paper in detail. 

Poland, who was not involved with the research, said the paper leaves out "important parameters" that could help scientists judge the work. 

"The results, such as they are presented, provide interesting data that are reassuring. ... This needs to be replicated and it needs to be peer-reviewed," he said.

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DocHolliday
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June 13, 2020 | 2:16 pm EDT Update

[image]

Dave Chappelle is not holding back in defense of his friend LeBron James while calling out Fox News host Laura Ingraham. In his new 27-minute Netflix special, “8:46” — named for the amount of time a Minneapolis police officer held his knee to George Floyd’s neck before Floyd died by asphyxiation — Chappelle uses a choice four-letter word for Ingraham while responding to her infamous “Shut up and dribble” comments.
 

– via ZagsBlog.com

“Let me tell you something about LeBron, this [guy] was on the cover of Sports Illustrated when he was 17 years old and exceeded every expectation that they had for him,” Chappelle said “…This is a good guy, LeBron. He didn’t let anyone down.” He added: “LeBron James once said something about racism, and Laura Ingraham…told one of Ohio’s greatest residents, ‘Shut up and dribble.’ “My friend is the best at something and this b—- is not the best at anything. She’s just a regular-ass white b—- with a platform.”
 

– via ZagsBlog.com
More from HoopsHype
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DocHolliday
If insurance companies want to do this great but isn't this a risk every player has faced going into an extension year?  Granted, a Covid related illness that causes permanent damage is one thing but isn't everything else the risk a player takes when they play?  I think if they're that afraid then either pay their own insurance or stay home and not go to Orlando as the league has stated their won't be any repercussions for those deciding to stay home (then they can sign their tens of millions of dollar contracts while healthy).  For some reason this has annoyed me but maybe (and probably) I'm missing something.

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RealGM WiretapRealGM Wiretap

Donovan Mitchell, Jayson Tatum, & Others Seek Insurance Policies For Potential Career-Threatening Injuries

JUN 13, 2020 4:01 PM

[Mitchell_Donovan_uta_171130]

Bam Adebayo, D'Aaron Fox, Kyle Kuzma, Donovan Mitchell and Jayson Tatum had a call with Players Association officials over the possibility of receiving league-financed insurance policies that would protect them against career-threatening injuries suffered in Orlando.

As part of the 2017 class, the five players are eligible for rookie extensions starting in the upcoming free agency period.

The five players believe they are taking on added personal risk due to the possibility of an increase in injuries after taking three months off.

The NBPA and NBA have previously discussed protections in the case of serious COVID-19 illness or career-threatening injury in Orlando.

Insurance policies for the five players could cost in the range of $500,000, though it would be difficult to prove that an injury affected future earnings unless it was career-ending. 

ADRIAN WOJNAROWSKI/ESPN

TAGS: KYLE KUZMABAM ADEBAYODONOVAN MITCHELLDE'AARON FOXJAYSON TATUMBOSTON CELTICSLOS ANGELES LAKERSMIAMI HEATSACRAMENTO KINGSUTAH JAZZNBANBA MISC RUMOR

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DocHolliday

 

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Coronavirus: Dexamethasone proves first life-saving drug

 
 

A cheap and widely available drug can help save the lives of patients seriously ill with coronavirus.

The low-dose steroid treatment dexamethasone is a major breakthrough in the fight against the deadly virus, UK experts say.

The drug is part of the world's biggest trial testing existing treatments to see if they also work for coronavirus.

It cut the risk of death by a third for patients on ventilators. For those on oxygen, it cut deaths by a fifth.

Had the drug had been used to treat patients in the UK from the start of the pandemic, up to 5,000 lives could have been saved, researchers say.


more.....




 
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LX
That was interesting news for me. My wife has had huge doses of dexamethasone weekly for a decade in order to treat her multiple myeloma. Hopefully there is a good effect as a result if need be.
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JeffB
Well, hope everyone is enjoying their sanitized masks. 🤮

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JeffB
Screenshot_20200706-085017_Twitter.jpg 
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moremilk
JeffB wrote:
Screenshot_20200706-085017_Twitter.jpg 


well, at least that's not as contagious and we have a proven treatment for it 🙂
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